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X-Chromosome Inactivation Compensates for Differences in Gene Dose

Men and women genomes together with differ from the most other sex chromosome, brand new X-chromosome, because females keeps twice the brand new serving off X-chromosomelinked genes one to men keeps. The fresh new X-chromosome contains up to 160 mil base sets from DNA (regarding 5 per cent of your total haploid genome) and encodes an estimated step one,000 in order to 2,000 genes (Figure 2–2). Because of the nature off X-chromosome-linked models out-of genetics, people are going to be possibly homozygous or heterozygous getting X-chromosome-connected characteristics, while guys, while they have only an individual X chromosome, try hemizygous. Of them X-chromosome-linked family genes recognized to day, most are X-chromosome certain; just pseudoautosomal genetics and some family genes one map beyond the new pseudoautosomal area was in fact demonstrated to has actually functionally equivalent Y-chromosome homologues (Willard, 2000). Czytaj więcej